| | Electro-Biotechnology | | BEST-Bio is a leading electrochemistry service provider to the pharmaceutical and biotechnology
industries focused on the application of electrochemical oxidation to drug discovery and drug/xenobiotic metabolite characterization. | | Our services in this space include: | | | Phase 1 Metabolism Studies - Using electrochemical oxidation to mimic Phase 1 oxidation reactions
in metabolism. This has the advantage over microsomes and cytochrome P450 because metabolites can be determined without the need for sample extraction
or matrix removal. | | Phase 2 Metabolism Studies - Using electrochemical oxidation with conjugation to nucleophiles including
glutathione, cysteine, model proteins, and physiologically relevant proteins. | | Synthesis of Metabolites - Electrochemical oxidative synthesis of drug and xenobiotic metabolites
on the micro/milligram scale for further characterization by NMR, HPLC, etc. or to provide standards for quantification. | | Electrochemical Cleavage of Peptides and Proteins - Using electrochemical oxidation of proteins and peptides
to cleave at tryptophan or tyrosine residues as an alternative to enzymatic protein digestion. | | DNA Adduct Formation - DNA adduct profiling by the electrochemical oxidation of nucleotides and drug molecules. | | | | | |
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